Automated closed-loop control of diabetes: the artificial pancreas
نویسندگان
چکیده
منابع مشابه
A bihormonal closed-loop artificial pancreas for type 1 diabetes.
Automated control of blood glucose (BG) concentration is a long-sought goal for type 1 diabetes therapy. We have developed a closed-loop control system that uses frequent measurements of BG concentration along with subcutaneous delivery of both the fast-acting insulin analog lispro and glucagon (to imitate normal physiology) as directed by a computer algorithm. The algorithm responded only to B...
متن کاملArtificial Pancreas Device Systems for the Closed-Loop Control of Type 1 Diabetes
BACKGROUND Closed-loop artificial pancreas device (APD) systems are externally worn medical devices that are being developed to enable people with type 1 diabetes to regulate their blood glucose levels in a more automated way. The innovative concept of this emerging technology is that hands-free, continuous, glycemic control can be achieved by using digital communication technology and advanced...
متن کاملClosed-Loop Artificial Pancreas Systems: Engineering the Algorithms
In this two-part Bench to Clinic narrative, recent advances in both the preclinical and clinical aspects of artificial pancreas (AP) development are described. In the preceding Bench narrative, Kudva and colleagues provide an in-depth understanding of the modified glucoregulatory physiology of type 1 diabetes that will help refine future AP algorithms. In the Clinic narrative presented here, we...
متن کاملA closed-loop artificial pancreas based on risk management.
BACKGROUND Control algorithms that regulate blood glucose (BG) levels in individuals with type 1 diabetes mellitus face several fundamental challenges. Two of these are the asymmetric risk of clinical complications associated with low and high glucose levels and the irreversibility of insulin action when using only insulin. Both of these nonlinearities force a controller to be more conservative...
متن کاملA Closed Loop Implantable Artificial Pancreas Using Thin Film
To prevent the onset of serious pathologies diabetics must maintain extremely close control over their glucose levels which requires as many as eight blood samplings a day, an onerous task. A long sought solution is to have glucose monitored by an implantable sensor which is coupled to an implanted insulin pump which would deliver insulin in response to the monitor signal. The paper describes t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioelectronic Medicine
سال: 2018
ISSN: 2332-8886
DOI: 10.1186/s42234-018-0015-6